J exp med

Potential mechanisms driving obesity-related inflammation, primarily in adipose tissue and other metabolic organs and implications of circulatory inflammatory factors on various metabolic and regulatory organs, j exp med. Chromosome 15 15q abnormality in patients with Prader-Willi syndrome and Angelman syndrome. WJEM accepts both solicited and unsolicited manuscripts. Articles published in WJEM are high-quality, clinical and basic, influential research articles by established academic authors as well as new researchers.

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J exp med

Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological , pathological , and molecular mechanisms that encompass the host response to disease. The journal prioritizes studies on intact organisms and has made a commitment to publishing studies on human subjects. The journal has no single editor-in-chief , but thirteen academic editors. Welch , the school's founder and also the first president of the Board of Scientific Directors of the Rockefeller Institute since renamed Rockefeller University. From its inception, Welch edited the journal by himself—even editing manuscripts while attending baseball games. By March , the editorial burden became too great for Welch, who stopped publishing papers and began stockpiling manuscripts and unanswered correspondence in his office, explaining the conspicuous absence of published papers from to In October , Welch appealed to the board of the Rockefeller Institute to take over the journal. The transfer of ownership and publication responsibilities required the physical transfer of manuscripts from Welch's office, which fell to the director of the Rockefeller Institute, Simon Flexner , who carried the abandoned manuscripts from Baltimore to New York City in a suitcase. The first issue published by the Rockefeller Institute appeared in February , with Flexner serving as editor, and the journal has been published regularly since then. Although the journal was adopted by the Rockefeller Institute as a venue for publication of the institute's own research, it also accepted submissions from outside. Even in the early years, more than half of the papers published in the journal came from external labs.

March 04 Cellular senescence: Neither irreversible nor reversible. The journal has no single editor-in-chiefbut thirteen academic editors.

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The intestine plays an important role in nutrient digestion and absorption, microbe defense, and hormone secretion. Although major cell types have been identified in the mouse intestinal epithelium, cell type-specific markers and functional assignments are largely unavailable for human intestine. Here, our single-cell RNA-seq analyses of 14, epithelial cells from human ileum, colon, and rectum reveal different nutrient absorption preferences in the small and large intestine, suggest the existence of Paneth-like cells in the large intestine, and identify potential new marker genes for human transient-amplifying cells and goblet cells. We have validated some of these insights by quantitative PCR, immunofluorescence, and functional analyses. Furthermore, we show both common and differential features of the cellular landscapes between the human and mouse ilea. Therefore, our data provide the basis for detailed characterization of human intestine cell constitution and functions, which would be helpful for a better understanding of human intestine disorders, such as inflammatory bowel disease and intestinal tumorigenesis. Abstract The intestine plays an important role in nutrient digestion and absorption, microbe defense, and hormone secretion. Publication types Research Support, Non-U. Substances Biomarkers.

J exp med

Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age. The largest reservoir of microbes exists in the distal gastrointestinal tract, both in the lumen, where microbes facilitate primary and secondary metabolism, and on mucosal surfaces, where they interact with host immune cell populations. While local microbial-driven immunomodulation in the gut is well described, more recent studies have demonstrated a role for the gut microbiome in influencing remote organs and mucosal and hematopoietic immune function. Unsurprisingly, therefore, perturbation to the composition and function of the gut microbiota has been associated with chronic diseases ranging from gastrointestinal inflammatory and metabolic conditions to neurological, cardiovascular, and respiratory illnesses. Considerable effort is currently focused on understanding the natural history of microbiome development in humans in the context of health outcomes, in parallel with improving our knowledge of microbiome-host molecular interactions. These efforts ultimately aim to develop effective approaches to rehabilitate perturbed human microbial ecosystems as a means to restore health or prevent disease. This review details the role of the gut microbiome in modulating host health with a focus on immunomodulation and discusses strategies for manipulating the gut microbiome for the management or prevention of chronic inflammatory conditions.

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All rights reserved. Manage Email Alerts. From its inception, Welch edited the journal by himself—even editing manuscripts while attending baseball games. Contents move to sidebar hide. Exploring the mechanism of action bitter melon in the treatment of breast cancer by network pharmacology. Even in the early years, more than half of the papers published in the journal came from external labs. Accessed February 23, In this issue of JEM , Boisserand et al. Hidden categories: CS1 errors: periodical ignored Articles with short description Short description is different from Wikidata Monthly journals infobox Articles with outdated impact factors from All articles with failed verification Articles with failed verification from July Official website different in Wikidata and Wikipedia. Current Issue. Advanced Search.

She has been a professional editor since when she joined Journal of Experimental Medicine as a scientific editor. She then pursued her postdoctoral research with Robert Darnell at The Rockefeller University, focusing on RNA-protein crosstalk in neurological diseases. She pursued her postdoctoral work with Abraham Brass and Kate Fitzgerald at University of Massachusetts Medical School, focusing on uncovering novel host factors in viral replication.

Articles published in WJEM are high-quality, clinical and basic, influential research articles by established academic authors as well as new researchers. Academic journal. Graphical abstract. March 07 Core Tip. Copyright to articles remains with the authors and third parties may re-use content after 6 months under the terms of a Creative Commons Attribution-Noncommercial-Share Alike 3. Exploring the mechanism of action bitter melon in the treatment of breast cancer by network pharmacology. Accessed February 23, In vitro study on the transmission of multidrug-resistant bacteria from textiles to pig skin. Skip Nav Destination. Research on nanosciences involvement in pharmaceutical education should be reinforced. Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological , pathological , and molecular mechanisms that encompass the host response to disease. Enhanced costimulatory molecule expression by cDC2 promotes prolonged T cell activation, integrin-dependent macro-clustering, and optimized cytokine sensing. February 28