Gudrun göhring

Genes, Chromosomes and Cancer54 12 ,

Nat Commun ;13 1 DOI: Epub Mar Cell Dev. Epub Jan Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells.

Gudrun göhring

T1 - Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome. N2 - To identify cytogenetic risk factors predicting outcome in children with advanced myelodysplastic syndrome, overall survival of children prospectively enrolled in European Working Group of Myelodysplastic Syndrome in Childhood studies was evaluated with regard to karyotypic complexity. Structurally complex constitutes a new definition of complex karyotype characterized by more than or equal to 3 chromosomal aberrations, including at least one structural aberration. Five-year overall survival in patients with more than or equal to 3 clonal aberrations, which were not structurally complex, did not differ from that observed in patients with normal karyotype. The presence of a structurally complex karyotype was the strongest independent prognostic marker predicting poor outcome in children with advanced myelodysplastic syndrome. AB - To identify cytogenetic risk factors predicting outcome in children with advanced myelodysplastic syndrome, overall survival of children prospectively enrolled in European Working Group of Myelodysplastic Syndrome in Childhood studies was evaluated with regard to karyotypic complexity. Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome. Overview Fingerprint. Abstract To identify cytogenetic risk factors predicting outcome in children with advanced myelodysplastic syndrome, overall survival of children prospectively enrolled in European Working Group of Myelodysplastic Syndrome in Childhood studies was evaluated with regard to karyotypic complexity. Access to Document

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CML is a rare form of leukemia among children and adolescents, but one of the common hematological diseases in older age. A number of clinical findings in pediatric CML suggest differences of leukemia cell or host biology compared with CML in adults. Aim of the clinical CMLpaed registry and the accompanying research projects is to understand the age dependent molecular and cellular features of the disease and their impact on the clinical management. J Cell Mol Med. Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial. Suttorp M, et al.

Blood ; 4 : — IDH2 mutations of amino acid or could be identified in This study was registered at www. In an attempt to discover unknown molecular alterations in patients with acute myeloid leukemia AML , whole genome sequencing was performed on AML patients. In the present study, we performed a comprehensive analysis of mutations occurring in exon 4 of IDH2 including both codons R and R in patients with CN-AML in the context of other known prognostic markers. These patients were intensively treated with a uniform protocol in 2 consecutive multicenter trials. Overall, our data indicate that IDH2 mutations in codons R and R are frequent but have no prognostic implications in patients with CN-AML when considered alone or in combination with IDH1 mutations and treated with these intensive protocols.

Gudrun göhring

Philadelphia chromosome-positive chronic myeloid leukemia CML is cytogenetically characterized by the classic translocation t 9;22 q34;q11 , whereas additional non-Philadelphia aberrations nPhAs have been studied extensively in adult patients with CML, knowledge on nPhAs in pediatric patients with CML is still sparse. Chromosome 15 was recurrently involved in variant translocations. No significant impact of the cytogenetic subgroup on the time point of cytogenetic response was observed. Patients with a complex karyotype showed an inferior molecular response compared to patients carrying the classic translocation t 9;22 q34;q11 , variant translocations or ACAs. No significant differences in the probability of progression-free survival and overall survival was found between patients with nPhAs and patients with the classic Philadelphia translocation only. Our results highlight the distinct biology of pediatric CML and underline the need for joint international efforts to acquire more data on the disease pathogenesis in this age group. Keywords: Philadelphia chromosome; additional chromosomal aberrations; chronic myeloid leukemia; complex karyotype; cytogenetic response; molecular response; pediatric chronic myeloid leukemia; tyrosine kinase inhibitor treatment; variant translocations. Abstract Philadelphia chromosome-positive chronic myeloid leukemia CML is cytogenetically characterized by the classic translocation t 9;22 q34;q11 , whereas additional non-Philadelphia aberrations nPhAs have been studied extensively in adult patients with CML, knowledge on nPhAs in pediatric patients with CML is still sparse.

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Science ; DOI: This Site. Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia. Schwaab, Juliana. Copyright by American Society of Hematology. In all patients, imatinib induced rapid and durable complete remissions. Regression analysis in health services research: the use of dummy variables. Your comment will be reviewed and published at the journal's discretion. In eosinophilia-associated myeloproliferative neoplasms MPN-eo , constitutive activation of protein tyrosine kinases TK as consequence of translocations, inversions, or insertions and creation of TK fusion genes is recurrently observed. Cross, Nicholas C. Author: Nicholas C. The partner genes contain domains like coiled-coil structures, which are likely to cause dimerization and activation of the TK.

Blood ; Supplement 1 : — Introduction: We evaluated low coverage whole genome sequencing WGS of acute myeloid leukemia AML patients using long read Oxford Nanopore Technology ONTseq for karyotyping and compared the results and the frequency of patients with myelodysplasia-related cytogenetic abnormalities according to previous and current AML classifications with conventional cytogenetics CG.

In: Blood. Close Abstract. Most studies defined a complex karyotype as more than or equal to 3 independent abnormalities. DNA copy number alterations mark disease progression in paediatric chronic myeloid leukaemia. Regression analysis in health services research: the use of dummy variables. Sci Rep. Article history Submitted:. Gene Ther ;24 5 This record has no associated files available for download. The online version of this article contains a data supplement. Hijiya N, et al.