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Phospholipase D PLD is a potential therapeutic target against cancer. However, the contribution of PLD inhibition to the antitumor response remains unknown. We developed a potent and selective PLD1 inhibitor based on computer-aided drug design. The inhibitor enhanced apoptosis in colorectal cancer CRC cells but not in normal colonic cells, and in vitro cardiotoxicity was not observed. In cancer, therapeutic engagement of immunogenic cell death ICD leads to more effective responses by eliciting the antitumor immunity of T cells. PLD1 inhibition subsequently enhanced the phagocytosis of cancer cells by macrophages through the surface expression of costimulatory molecules; as a result, the cancer cells were more susceptible to cytotoxic T-cell-mediated killing. Moreover, PLD1 inhibition attenuated colitis-associated CRC and orthotopically injected tumors, probably by controlling multiple pathways, including Wnt signaling, phagocytosis checkpoints, and immune signaling.

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Lau 4,5,6,7 , Kenneth K. Leung 4 , Adrienne Y. Chan 4,5,6,10 , Celine S. Chui 6,11,12 , Ian C. Wong 4,5,6,7,13 , Ju-Young Shin 1,2, Background Polypharmacy among older people represents a global challenge due to its association with adverse drug events. The reported prevalence of polypharmacy varies widely across countries, and is particularly high in Asian countries. However, there is no multinational study using standardised measurements exploring variations in prescribing trends. Design Multinational, retrospective, time-trend, observational study using a common study protocol. We estimated the annual prevalence of polypharmacy and calculated average annual percentage change AAPC to assess the time trends. Results A total of 1. The highest prevalence of polypharmacy was observed in Hong Kong Conclusions Polypharmacy prevalence in older people was higher in Hong Kong, Taiwan and South Korea, with an increasing trend over time, compared with Australia and the United Kingdom. Our findings underline the necessity to monitor polypharmacy among older people in Asia by conducting government-level interventions and introducing medicine-optimisation strategies.

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Lee was in a relationship with Jun Hyun-moo , a former announcer turned broadcast personality and host. This biographical article about a South Korean personality is a stub. You can help Wikipedia by expanding it. This Asian biographical article related to television is a stub. Contents move to sidebar hide. Article Talk. Read Edit View history.

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Lyrics Add lyrics on Musixmatch. Monday 29 January Sunday 31 December Tuesday 23 January Sunday 28 January Wednesday 25 October Saturday 4 November Monday 27 November Thursday 25 January Sunday 17 December Go directly to shout page. Furthermore, combination therapy with a PLD1 inhibitor and an anti-PD-L1 antibody further enhanced tumor regression via immune activation in the tumor environment.

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