Tetrahydroquinoline

Thank you for visiting nature. You are tetrahydroquinoline a browser version with limited support for CSS.

JavaScript seems to be disabled in your browser. You must have JavaScript enabled in your browser to utilize the functionality of this website. Chem Service, Inc. West Chester, PA Email to a Friend.

Tetrahydroquinoline

Don't have a profile? This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. No offer available. Gel Electrophoresis Equipment and Supplies. View All Antibodies. Antibodies Advanced Search. Biochemicals and Reagents. Biological Buffers. Custom Services and Products. Enzymes and Inhibitors.

An tetrahydroquinoline friendly iridium-catalyzed direct cyclization of N -methylanilines with 1,3-propanediol provides tetrahydroquinolines with water as the sole by-product. Article PDF, tetrahydroquinoline.

Maurya, O. Patel, D. Anand and P. Yadav, Org. To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page. If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given. If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given.

Federal government websites often end in. The site is secure. A review of the recent literature is given focusing on synthetic approaches to 1,2,3,4-tetrahydroquinolines, 2,3-dihydro-4 1 H -quinolinones and 4 1 H -quinolinones using domino reactions. These syntheses involve: 1 reduction or oxidation followed by cyclization; 2 S N Ar-terminated sequences; 3 acid-catalyzed ring closures or rearrangements; 4 high temperature cyclizations and 5 metal-promoted processes as well as several less thoroughly studied reactions. Each domino method is presented with a brief discussion of mechanism, scope, yields, simplicity and potential utility. Domino reactions, also known as tandem or cascade reactions, have emerged as a highly effective strategy for the synthesis of bioactive natural products and pharmaceutical agents [ 1 ]. These methods enable chemists to perform complex synthetic conversions with high efficiency using simple starting materials, often via a biomimetic pathway [ 2 ]. Thus, domino reactions contribute immensely to synthetic drug design strategies, enhance aesthetic approaches in total synthesis, and improve yields in large-scale synthesis [ 1 , 2 ]. The advantages of these methods include excellent atom economy, high selectivity, and less waste [ 3 , 4 ]. Additionally, using these strategies, multiple transformations can be carried out in a single laboratory operation without the isolation of intermediates making them prime examples of green chemistry [ 5 , 6 ].

Tetrahydroquinoline

Xiong, S. Li, B. Fu, J. Wang, Q. Wang, W. Yang, Org. A chiral phosphoric acid as the sole catalyst enables an enantioselective synthesis of tetrahydroquinolines from 2-aminochalcones via chiral phosphoric acid-catalyzed dehydrative cyclization, followed by chiral phosphoric acid-catalyzed asymmetric reduction with Hantzsch ester. Various 2-aminochalcones could be applicable to this protocol, and the desired tetrahydroquinolines were obtained in excellent yields and with excellent enantioselectivities. Park, S.

Sfse

By submitting a comment you agree to abide by our Terms and Community Guidelines. See All Categories. Download Citation. Akiyama, H. View All PCR. Yu, M. Weighing Papers and Dishes. Specifications Melting Point Request permissions. Privacy Policy. Contact Us Distributors. With the proper choice of palladium catalyst, ligand, and base, five-, six-, and seven-membered rings are formed efficiently from secondary amide or secondary carbamate precursors. Watanabe, S.

Tetrahydroquinoline is an organic compound that is the semi-hydrogenated derivative of quinoline. It is a colorless oil.

Han, H. Chen, M. Das, Synlett , , 34 , Please enable JavaScript to access the full features of the site or access our non-JavaScript page. Recombinant Proteins Recombinant Proteins. PCR Tubes. From the journal: Organic Chemistry Frontiers. Nature , Xiong, S. Anyone you share the following link with will be able to read this content:. Du, Y. Using the cyclic hydroxylamines allows for retaining both nitrogen and oxygen functionalities in the product. Request permissions. About us. Hu, X.