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Federal government websites often end in. The site is secure. Macrophage infectivity potentiator Mip and Mip-like proteins are virulence factors in a wide range of pathogens including Legionella pneumophila. Additionally, Mip is a moonlighting protein that binds to collagen IV in the extracellular matrix. Here, we describe the development and synthesis of cycloheximide derivatives with adamantyl moieties as novel FKBP ligands, and analyze their effect on the viability of L. Five of these derivatives inhibited the growth of L.

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Molecular cloning of a Coxiella burnetii gene encoding a macrophage infectivity potentiator Mip analogue.

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No use, distribution or reproduction is permitted which does not comply with these terms. In the search for novel FKBP inhibitors without immunosuppressive side effects, we decided to extend the number of derivatives of the already described imide substituted cycloheximide compounds Christner et al. Federal government websites often end in. Turn the oven off and remove the power 6. It is occasionally necessary to remove the glass tray plug from the wall socket before cleaning. This article was submitted to Bioinformatics and Computational Biology, a section of the journal Frontiers in Bioengineering and Biotechnology. B Adamantane was identified by structure based computational modeling as an appropriate scaffold that can replace the pipecolinic acid moiety in FK, which interacts with the PPIase active cleft of FKBPs. As a library, NLM provides access to scientific literature. Front Bioeng Biotechnol. Non-macrolide FKBP-inihibitors. Abstract Macrophage infectivity potentiator Mip and Mip-like proteins are virulence factors in a wide range of pathogens including Legionella pneumophila.

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Sign In OR. Figure 3. The graph shows the mean and SD of two independent experiments performed in triplicate. It is occasionally necessary to remove the glass tray plug from the wall socket before cleaning. A 28 kDa major immunogen of Chlamydia psittaci shares identity with Mip proteins of Legionella spp. Hide thumbs. Structure and function of the molecular chaperone trigger factor. B Adamantane was identified by structure based computational modeling as an appropriate scaffold that can replace the pipecolinic acid moiety in FK, which interacts with the PPIase active cleft of FKBPs. Delete from my manuals? For infection, L. References Babine R. Rename the bookmark. Briefly, THP-1 cells were prepared as described above. Published online Mar It is advisable never to 7.