Sv40

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Skip to content. Polio vaccines used in the late s and early s were contaminated with a virus called simian virus 40 SV40 present in monkey kidney cells used to grow the vaccine. Subsequently, investigators found SV40 DNA in biopsy specimens obtained from patients with cancers such as mesothelioma lung , osteosarcoma bone and non-Hodgkins lymphoma lymph nodes. However, several facts should be noted:. Taken together, these findings do not support the hypothesis that SV40 virus contained in polio vaccines administered before caused cancers. Carroll-Pankhurst, C.

Sv40

Federal government websites often end in. The site is secure. Since its discovery, simian virus 40 SV40 has been one of the most intensely studied animal viruses. The molecular biology of SV40 has led to seminal discoveries in the fields of transcription, DNA replication, and oncogenic transformation Over the last decade, provocative evidence has accumulated that suggests that SV40 may be a human pathogen. Does SV40 infect humans? If so, when did this monkey polyomavirus enter the human population and where is the reservoir? What is the behavior of SV40 in human cells? Does it cause or contribute to acute or chronic disease? Other comprehensive reviews have also addressed these issues, with a variety of emphases 8 , 10 , 52 , 57 , In , Sweet and Hilleman first described an agent, which they named SV40, that induced cytopathic effects and vacuole formation in monkey cells SV40 was isolated from normal monkey kidney cells, stocks of the Sabin poliovirus vaccine, and an adenovirus vaccine.

Pipkin, Z. Pond, et al. Oncogene 13 :

Infectious Agents and Cancer volume 2 , Article number: 13 Cite this article. Metrics details. Simian virus 40 SV40 is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells. Recent molecular biology and epidemiological studies suggest that SV40 may be contagiously transmitted in humans by horizontal infection, independently from the earlier administration of SVcontaminated vaccines. SV40 footprints in humans have been found associated at high prevalence with specific tumor types such as brain and bone tumors, mesotheliomas and lymphomas and with kidney diseases, and at lower prevalence in blood samples from healthy donors. Contrasting reports appeared in the literature on the circulation of SV40 in humans by contagious transmission and its association, as a possible etiologic cofactor, with specific human tumors. As a consequence of the conflicting results, a considerable debate has developed in the scientific community.

Skip to content. Polio vaccines used in the late s and early s were contaminated with a virus called simian virus 40 SV40 present in monkey kidney cells used to grow the vaccine. Subsequently, investigators found SV40 DNA in biopsy specimens obtained from patients with cancers such as mesothelioma lung , osteosarcoma bone and non-Hodgkins lymphoma lymph nodes. However, several facts should be noted:. Taken together, these findings do not support the hypothesis that SV40 virus contained in polio vaccines administered before caused cancers. Carroll-Pankhurst, C. Engels, H. Strickler, et al. Engels, E.

Sv40

Infectious Agents and Cancer volume 2 , Article number: 13 Cite this article. Metrics details. Simian virus 40 SV40 is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells. Recent molecular biology and epidemiological studies suggest that SV40 may be contagiously transmitted in humans by horizontal infection, independently from the earlier administration of SVcontaminated vaccines. SV40 footprints in humans have been found associated at high prevalence with specific tumor types such as brain and bone tumors, mesotheliomas and lymphomas and with kidney diseases, and at lower prevalence in blood samples from healthy donors.

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Pipas, and T. Pass, and R. Fields, D. Now, prospective studies are needed to determine the prevalence of SV40 infections in different human populations and to assess how the virus is transmitted from person to person. In this review we evaluate the biological, pathological and clinical evidence of SV40 in human cancers, non-malignant diseases and blood samples. Clinical Microbiology Reviews. Fischer, K. E-mail: ude. Polyomaviruses are small, nonenveloped, icosahedral DNA viruses. Genetic analysis of simian virus 40 from brains and kidneys of macaque monkeys. Murakami, Y. Jensen, J. Sacco, F.

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However, most of these early serologic studies were carried out before the discovery of the two human polyomaviruses, BK and JC, which are close related to SV40 and are ubiquitous in human populations. White, J. Indeed, several steps need to be considered when performing molecular studies of human specimens 1 , 50 , 61 , Natural simian virus 40 strains are present in human choroid plexus and ependymoma tumors. Pepper, C. Download citation. Friend, L. Pass, I. This finding may also explain the lack of difference in cancer incidence between individuals vaccinated with SVcontaminated and SVfree anti-polio vaccines [ 82 ]. Martini, M. The Tag-C sequence was shown to be stable during the tissue culture passage of SV40 isolates [ ].