Stilbene

Federal government websites often end in, stilbene. The site is secure. BoxKuopio, Finland. Numerous studies have highlighted the key roles of oxidative stress and inflammation in aging-related diseases such as obesity, type stilbene diabetes, age-related macular stilbene AMDand Alzheimer's disease AD.

Classified as a diarylethene , it features a central ethylene moiety with one phenyl group substituent on each end of the carbon—carbon double bond. It has an E stereochemistry, meaning that the phenyl groups are located on opposite sides of the double bond, the opposite of its geometric isomer , cis -stilbene. Trans -stilbene occurs as a white crystalline solid at room temperature and is highly soluble in organic solvents. It can be converted to cis -stilbene photochemically , and further reacted to produce phenanthrene. Stilbene was discovered in by the French chemist Auguste Laurent. Stilbene exists as two possible stereoisomers.

Stilbene

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Download as PDF Printable version. Structure-activity relationships of resveratrol and derivatives in breast cancer cells, stilbene.

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Federal government websites often end in. The site is secure. Box , Kuopio, Finland. Numerous studies have highlighted the key roles of oxidative stress and inflammation in aging-related diseases such as obesity, type 2 diabetes, age-related macular degeneration AMD , and Alzheimer's disease AD. In aging cells, the natural antioxidant capacity decreases and the overall efficiency of reparative systems against cell damage becomes impaired.

Stilbene

Federal government websites often end in. The site is secure. Stilbenes are polyphenolic allelochemicals synthesized by plants, especially grapes, peanuts, rhubarb, berries, etc. They are now exploited in medicine for their antioxidant, anti-proliferative and anti-inflammatory properties. It is characterized by the release of cytokines which can wreak havoc on healthy tissues, worsening the disease condition. Resveratrol, the most studied stilbene, lowers the Michaelis constant of SIRT1, and occupies the substrate binding pocket. Gigantol interferes with the complement system. Besides these, oxyresveratrol, pterostilbene, polydatin, viniferins, etc. However, they each have different thresholds for toxicity to various cells of the human body, and thus a careful review of their properties must be conducted. In animal models of autoinflammatory diseases, the mode of application of stilbenes is important to their absorption and curative effects, as seen with topical and microemulsion gel methods.

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Experimental Eye Research. Kubo I. Recently, a very interesting long-term trial determining the impact of resveratrol supplementation on adipose tissue, insulin signaling, and inflammatory response was reported using rhesus monkeys as the model [ ]. However, one recent report suggested that part of the beneficial metabolic impacts may not simply be due to general CR, but also the food ingredients in the CR diet may play a role since those individuals consuming a CR diet had high intakes of vegetables, berries, and fruits which contain substantial amounts of bioactive compounds [ ]. Current Alzheimer Research. Toxicology and Applied Pharmacology. Importantly, resveratrol was able to activate AMPK in neuronal cells in vitro as well as in the brain and it enhanced activation of mitochondrial biogenesis in an AMPK-dependent manner [ ]. By inhibiting the action of these enzymes with drugs e. Jeandet P. Box , Kuopio, Finland. Free Radical Biology and Medicine. RPE lipofuscin and its role in retinal pathobiology.

Federal government websites often end in. The site is secure.

Alp N. Fischer-Posovszky P. Qin S. Agarwal B. Lin H. Journal of Biological Chemistry. Metals, oxidative stress and neurodegenerative disorders. Viiri J. Lee J. Tanzi R. Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Importantly, it was also observed that the improved behavioral performance was associated with increases in total CREB and elevated levels of pro- and mature BDNF in the hippocampus.