Salvia miltiorrhiza

The specific epithet miltiorrhiza means "red ochre root".

Federal government websites often end in. The site is secure. Salvia miltiorrhiza Bunge, also known as Danshen in Chinese, has been widely used to treat cardiovascular diseases CVD in China and other Asia countries. Here, we summarize literatures of the historical traditional Chinese medicine TCM interpretation of the action of Salvia miltiorrhiza, its use in current clinical trials, its main phytochemical constituents and its pharmacological findings by consulting Pubmed, China Knowledge Resource Integrated, China Science and Technology Journal, and the Web of Science Databases. Since , 39 clinical trials have been identified that used S. More than individual compounds have been isolated and characterized from S.

Salvia miltiorrhiza

Chinese Medicine volume 5 , Article number: 22 Cite this article. Metrics details. Danshen , the dried root of Salvia miltiorrhiza , is a Chinese medicine used to promote blood flow and treat vascular disease. The present article reviews the pharmacological effects of Danshen on cerebral infarction and possible interactions between Danshen and Western drugs. Danshen may reduce or prolong the development of atherosclerosis and may have anti-hypertensive and anti-platelet aggregation effects, which prevent cerebral infarction. Danshen may enhance endogenous anti-oxidative enzyme activities such as the expression of endothelial nitric oxide synthase and may scavenge oxygen free radicals. Prevention and treatment of cerebral infarction by Danshen involves multiple pathways, including anti-atherosclerosis, anti-hypertension, anti-platelet aggregation, anti-inflammatory and anti-oxidative effects. Danshen , the dried root of Salvia miltiorrhiza , is used in Chinese medicine to treat vascular disease. According to Chinese medicine theory, Danshen promotes blood flow and resolves blood stasis. Cerebral infarction is an ischemic condition of the brain including thrombosis, embolism or systemic hemodynamic hypotension.

Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. Cell Adhes Migrat. The observation on salvia miltiorrhiza therapeutic effect of Shenfu Injection in the treatment of cases of chronic heart failure.

Salvia miltiorrhiza Bunge SM is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The present review is an up-to-date summary of the published scientific information about the traditional uses, chemical constituents, pharmacological effects, side effects, and drug interactions with SM, in order to lay the foundation for further investigations and better utilization of SM. SM contains diverse chemical components including diterpenoid quinones, hydrophilic phenolic acids, and essential oils. Many pharmacological studies have been done on SM during the last 30 years, focusing on the cardiovascular and cerebrovascular effects, and the antioxidative, neuroprotective, antifibrotic, anti-inflammatory, and antineoplastic activities. The research results strongly support the notion that SM has beneficial therapeutic properties and has a potential of being an effective adaptogenic remedy. Published by Elsevier B.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Salvia miltiorrhiza is one of the most widely used traditional medicines. The first gene is involved in the biosynthesis of bioactive tanshinones, the next two are involved in anthocyanin biosynthesis, whereas the last is involved in phenylpropanoid biosynthesis. The results suggest that S. They potentially play significant regulatory roles in the biosynthesis of bioactive compounds. Natural antisense transcripts NATs are a class of long noncoding RNAs, which transcribe in the opposite direction of protein-coding genes 1. Relatively, the transcripts of protein-coding genes were called sense transcripts STs.

Salvia miltiorrhiza

Federal government websites often end in. The site is secure. Salvia miltiorrhiza Bunge S. Considering its extensive usage as a therapeutic agent for multiple diseases, there is a need to review previous research regarding its therapeutic benefits and their mechanisms. Therefore, we searched PubMed and PubMed Central for articles reporting its therapeutic effects on certain disease groups including cancers, cardiovascular, liver, and nervous system diseases. This review provides an overview of therapeutic benefits and targets of S. The findings on multi-functional properties of S. It is a deciduous perennial plant which belongs to genus Salvia of Lamiaceae family [ 2 ].

City mall restaurantes

As a library, NLM provides access to scientific literature. Clinical efficacy: Markedly improved Prevention and treatment of cerebral infarction by Danshen involves multiple pathways, including anti-atherosclerosis, anti-hypertension, anti-platelet aggregation, anti-inflammatory and anti-oxidative effects Additional file 1. Danshen , the dried root of Salvia miltiorrhiza , is a Chinese medicine used to promote blood flow and treat vascular disease. Ineffective 0. Linton M. Virchows Arch. Lin, TH. And data about clinical information of hospitalized patients and outpatients with coronary artery disease and hypertension have demonstrated that S. Protective effects of salvianolate on microvascular flow in a porcine model of myocardial ischaemia and reperfusion. In Chinese. Beijing: China Medical Science Press; Protection of salvianolate against atherosclerosis via regulating the inflammation in rats. NO mediates glutamate neurotoxicity and the inhibition of NO synthase may prevent the development of brain edema. Meanwhile, increased MMP-2 activity potentiates inflammation insults and plaque instability in the injured vascular wall [ ].

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer.

China Modern Doctor. Ineffective: No obvious improvement in ECG, or even appeared myocardial infarction during the attack. Panax notoginseng Sanqi is also used to treat vascular disorders. Chin Herb Pharmacol Clin. Roffe S. Beneficial effects of a polysaccharide from Salvia miltiorrhiza on myocardial ischemia-reperfusion injury in rats. Sun L. Garlic , Borneolum Synthcticum. Gao Z. Modern Med Health. Cheng K. Postmenopausal women with borderline hypercholesterolemia 85 12 months.