Molecular therapy oncolytics

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View the family homepage Submit Your Research. ASGCT members receive online subscriptions to the Molecular Therapy journals to stay up to date on the latest research in the field. Here's how to claim your subscription:. Claim Your Subscription. MT is dedicated to publishing important peer-reviewed research and cutting-edge reviews and commentaries promoting genetics, medicine, and biotechnology. MTMCD focuses on advances in cell and gene therapy and how they are translated and applied in the clinical setting. MTO focuses on the development and testing of cancer therapies in pre-clinical and clinical settings, and provides a unique forum for work in the burgeoning fields of biologic cancer therapies including viral, bacterial, cellular, and gene therapy.

Molecular therapy oncolytics

Cell Press. How to publish in this journal. The set of journals have been ranked according to their SJR and divided into four equal groups, four quartiles. Q1 green comprises the quarter of the journals with the highest values, Q2 yellow the second highest values, Q3 orange the third highest values and Q4 red the lowest values. The SJR is a size-independent prestige indicator that ranks journals by their 'average prestige per article'. It is based on the idea that 'all citations are not created equal'. SJR is a measure of scientific influence of journals that accounts for both the number of citations received by a journal and the importance or prestige of the journals where such citations come from It measures the scientific influence of the average article in a journal, it expresses how central to the global scientific discussion an average article of the journal is. Evolution of the number of published documents. All types of documents are considered, including citable and non citable documents. This indicator counts the number of citations received by documents from a journal and divides them by the total number of documents published in that journal. The chart shows the evolution of the average number of times documents published in a journal in the past two, three and four years have been cited in the current year. Evolution of the total number of citations and journal's self-citations received by a journal's published documents during the three previous years. Journal Self-citation is defined as the number of citation from a journal citing article to articles published by the same journal. Evolution of the number of total citation per document and external citation per document i.

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Oncolytic viruses mediate antitumor responses through direct tumor cell lysis and induction of host antitumor immunity. However, the therapeutic efficacy of oncolytic viruses against malignant ascites has rarely been explored. This study aimed to evaluate the efficacy, safety, and immunomodulatory effect of an intraperitoneal injection of human type 5 recombinant adenovirus called H against malignant ascites. Forty patients with malignant ascites were recruited and treated with intraperitoneal H in the Fudan University Shanghai Cancer Center. The 4-week clinical responses were determined by an objective assessment of ascites volume change. Hmeditated tumor-specific immune activation on day 14 post-treatment was further identified by enzyme-linked immunospot assay. In conclusion, intraperitoneal H administration was well tolerated and effective in treating malignant ascites; thus, its immune activation ability may be a promising tool in combination with immunotherapy. Keywords: antitumor immune response; immunotherapy; malignant ascites; mass cytometry; oncolytic viruses. Abstract Oncolytic viruses mediate antitumor responses through direct tumor cell lysis and induction of host antitumor immunity.

Molecular therapy oncolytics

Application in antiviral discovery and disinfection procedures. Conventional cancer treatments have limited effectiveness in many cases. Oncolytic therapy, based on the use of armed viruses directed against tumor cells, offers new perspectives in the fight against this global scourge. Using autofluorescent viruses, we can measure the impact of the presence of a molecule of interest on virus infection and replication capacities. Our technology allows us to quickly calibrate and validate the development of disinfection devices. We can offer different types of imaging and also image analysis whether in a viral or non-viral context, from high content imaging to high resolution imaging and light sheet microscopy. Having the ability to directly visualize virus infection and replication in living cells using a breakthrough technology with minimum hands-on investment. This is what we propose at NeoVirTech. Our state of the art imaging and screening platform provides a rapid and powerful pipeline to discover compounds that will impact infection capacities and measure disinfection procedures on a large collection of viruses in the human and veterinary market.

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SJR is a measure of scientific influence of journals that accounts for both the number of citations received by a journal and the importance or prestige of the journals where such citations come from It measures the scientific influence of the average article in a journal, it expresses how central to the global scientific discussion an average article of the journal is. To serve the field best, Dr. Timothy P. It is an exciting time in cancer therapy, and with this journal rebranding, it is also an exciting time for Molecular Therapy Oncology. Ratio of a journal's items, grouped in three years windows, that have been cited at least once vs. Their timing was right on, as it was concurrent with the first FDA approval of an anti-PD-1 antibody, and the following year, we saw the first FDA approval of an oncolytic virus as a cancer therapy. The chart shows the ratio of a journal's documents signed by researchers from more than one country; that is including more than one country address. View Current Issue. The site is secure. Want to request permission to use information in Molecular Therapy? Given all the exciting developments across a wide range of cancer therapy technologies in the decade since our launch, it is important we return to the original, broader vision of the ASGCT leadership and of the inaugural MTO editor-in-chief, Yuman Fong. Not every article in a journal is considered primary research and therefore "citable", this chart shows the ratio of a journal's articles including substantial research research articles, conference papers and reviews in three year windows vs. The set of journals have been ranked according to their SJR and divided into four equal groups, four quartiles. Mitra A. Read Statements.

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Cell Press. Contact the editors-in-chief of each journal as well as Cell Press communications and advertising staff here. Furthermore, to provide expert management and review of a broader diversity of submissions, we plan to expand the expertise of our editorial board and our associate editors. View Current Issue. Ethical Statements Read Molecular Therapy 's ethical statements on authorship, dual submission, competing interests, inclusion and diversity, and more. Journal Self-citation is defined as the number of citation from a journal citing article to articles published by the same journal. Request Permission. Sadly, there has not yet been another oncolytic virus on the US market, though a few have received conditional approvals in other countries. Mitra A. Permissions Want to request permission to use information in Molecular Therapy? No bacterial therapies have yet been approved, but there are numerous ongoing trials. MT is dedicated to publishing important peer-reviewed research and cutting-edge reviews and commentaries promoting genetics, medicine, and biotechnology.