Milk thistle zararları

Federal government websites often end in. The site is secure. Widespread use of herbal drugs because of their protective effects on different organs toxicity has been shown in many studies.

How to use: For adults, it is recommended to take 1 capsule 2 times a day after meals and dissolve 1 sachet in a glass ml of water once a day and take after meals. Recommended consumption date and lot number are on the packaging. Store at room temperature, protect from heat and light. Additional Information: Do not exceed the recommended daily dose. Supplements cannot replace a normal diet. Keep out of reach of children. It is not a medicine.

Milk thistle zararları

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Reactive oxygen species can damage the cell membrane structure and destruct protein functions, especially enzymes. According to previous studies, milk thistle zararları, silymarin has antioxidant activities in the central nervous system, which enables it to enter the CNS via the blood—brain barrier BBB 48 -

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Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. Other benefits include promoting healthy digestive function, increasing bile production , decreasing inflammation and soothing the mucous membranes throughout the body. The milk thistle plant is a popular herb that has actually been used for over 2, years. The plant is native to the Mediterranean region and a member of the Asteraceae plant family, which also includes other plants like sunflowers and daisies. Milk thistle is commonly used for everything from weight loss to skin health to promoting breast milk production. However, while there are many different potential benefits, it is most well-known for being a natural liver supporter and is sometimes used to help treat liver diseases such as cirrhosis, jaundice and hepatitis, as well as gallbladder problems. There are a variety of milk thistle products available, and the seeds and leaves of the milk thistle plant can be consumed either in pill, powder, tincture, extract or tea form. The seeds can actually be eaten completely raw, too, but usually people prefer to take a milk thistle extract or supplement in order to consume a higher dose and see greater results. As a liver support and liver aid, milk thistle acts as a powerful liver cleanser by rebuilding liver cells, reducing liver damage and removing toxins from the body that are processed through the liver.

Milk thistle zararları

Milk thistle Silybum marianum is a herb loaded with antioxidants and is known for its anti-inflammatory properties. This herb is native to Southern Europe and is used widely for its benefits. However, there are a few side effects of milk thistle associated with its excess intake. Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. Learn more about the other negative effects of this herb and what research says about them. Continue reading. Long-Term Effects May aggravate conditions like endometriosis, and lower blood sugar levels too much. Drug Interactions It can interact with drugs like estrogen pills, statin drugs, which are known to lower cholesterol levels, and diabetes medications.

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Larner, et al. HepG2 -cells death occurs via inhibition of Akt kinase stimulated by palmitate exposure and silymarin prevents this inhibition as it has hepatoprotective activity different from its antioxidant property Silymarin elevates absorption and bioavailability of chemo-pharmaceutics such as daunomycin, vinblastine, and doxorubicin in cancerous cells by inhibition of P-glycoprotein P-gp , MRP1-mediated drug carrier and breast cancer resistance protein BRCP 4 , 6 , 9. Gynecol Endocrinol. Moreover, this herb has been used for centuries as a natural treatment for upper gastrointestinal tract and digestive problems, liver and biliary tract diseases, menstrual disorders and varicose veins 4 , 5. Findings in animal and human studies revealed the highest concentrations and therefore the more effects of silymarin in the liver Cambridge University Press, pp. The possible known mechanisms of action of silymarin protection are blockade and adjustment of cell transporters, p-glycoprotein, estrogenic and nuclear receptors. It also reduces the alanine aminotransferase and aspartate aminotransferase levels and suppressed the apoptosis in hepatocytes 4 , A primary role for MRP2, a cell membrane transporter, has been showed in the biliary excretion of silymarin conjugates. In animal models, silymarin active components had protective effects against hepatotoxic medications for chemotherapy of tuberculosis Dietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation and renal tumor promotion response. Hence, it can be used as a promising medication in complementary medicine. J Ethnopharmacol. It stimulates T-cell transcription factor and plays an important role in regulation of oncogenic process, as well as anti-apoptotic effects in various cancers.

One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. Silymarin is believed to have antioxidant properties. Milk thistle is sold as an oral capsule, tablet and liquid extract.

Silymarin inhibits in vitro t-cell proliferation and cytokine production in hepatitis c virus infection. Protective effects of Silymarin against free radical-induced erythrocyte lysis. Silymarin elevates absorption and bioavailability of chemo-pharmaceutics such as daunomycin, vinblastine, and doxorubicin in cancerous cells by inhibition of P-glycoprotein P-gp , MRP1-mediated drug carrier and breast cancer resistance protein BRCP 4 , 6 , 9. Pre-treatment of male mice with silymarin modulated the alteration of oxidative stress, cell cycle, cytoskeletal network, cell—cell adhesion, extra-cellular matrix, inflammation, apoptosis, cell-signaling and intermediary metabolism that was induced by pyrogallol. Prostate cancer chemoprevention by silybinin: bench to bedside. Physiol Res. Consult your doctor in case of pregnancy and lactation, illness or drug use. Karimi G. Thus, liver diseases remain one of the serious health problems. Liver damage ranges from acute hepatitis to hepatocellular carcinoma, being caused through apoptosis, necrosis, inflammation, immune response, fibrosis, ischemia, altered gene expression, and regeneration