Macquarie university dementia research centre

Lars graduated from the University of Ulm in Germany and completed his thesis at the University … View full profile.

The past decades of drug development have focused on clearing amyloid or reducing its formation but unfortunately have all failed to deliver. Hence, there is an unmet need for new therapeutic avenues in dementia. The multidisciplinary team of the Dementia Research Centre works closely with medicinal chemists and international pharmaceutical industry to accelerate translation into novel therapies for these devastating diseases. To treat dementia, it is vital to first understand the processes that lead to neuronal dysfunction and brain atrophy. Here, the team of the Dementia Research Centre has made fundamental discoveries that shed new light on the causes of dementia.

Macquarie university dementia research centre

Please also feel free to contact us if you are not eligible for any of the studies below, or if you have any suggestions or questions. We will keep you in mind for our next study or put you in contact with other researchers who may be able to help you. You will also do some cognitive tests, answer questionnaires, provide a blood sample and have some body measurements taken. You may chose to have an optional lumbar puncture to collect cerebral spinal fluid CSF. After that you will receive information on studies you are eligible for and you can decide if you would like to participate. If you would like to volunteer, please contact the team at: E: adnet. Previous work by Professor Ralph Martins and his team has found that the effects of testosterone therapy may extend to both the accumulation and clearance of amyloid beta from the brain and may potentially prevent the disease. The project will also study the effects of omega-3 fatty acids found in fish oil called DHA Docosahexaenoic Acid. DHA is thought to protect brain cells from the damage caused by the accumulation of amyloid beta. It is hoped that combining fish oil with testosterone will have a stronger preventative effect. Man concerned about their memory, aged 60 to 80, free from any major or unstable medical conditions, who have a testosterone level on the low side of normal, and are not currently taking testosterone treatment. You would like volunteer and do not know your testosterone level; we would still love to hear from you. We will collect a blood sample and test it for you. Participation requires initial screening to identify volunteers who are safe and suitable to take part.

Disease mechanisms Press the 'Space' or 'Enter' key to toggle the additional content To treat dementia, it is vital to first understand the processes that lead to neuronal dysfunction and brain atrophy.

The DRC currently includes eight research groups. The teams at the Dementia Research Centre currently have more than 10 different therapeutic development programs at different stage of pre-clinical testing. These include small molecules, antibodies and gene therapy approaches. Most of these proprietary molecules and drug targets are based on novel discoveries of disease mechanisms made over the past decade. AAVs are particularly well suited for gene delivery into cells and living organisms, including for gene therapy in humans.

Research output Research output per year 67 Article 12 Review article 3 Chapter 2 Editorial 1 More 1 Preprint. Research output per year. Open Access. An overview of in vitro and in vivo techniques for characterization of intranasal protein and peptide formulations for brain targeting Wong, C. Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy Forrest, S. Current concepts of mixed pathologies in neurodegenerative diseases Forrest, S. Dysregulated actin dynamics and cofilin correlate with TDP pathology in sporadic amyotrophic lateral sclerosis Jagaraj, C.

Macquarie university dementia research centre

The treatment works by focusing on a naturally protective enzyme in the brain called p38gamma, which when activated prevents the toxic effects of memory loss. Dementia is the leading cause of death of women and the second leading cause of death of all Australians. Brothers Lars and Arne Ittner, from Macquarie's Dementia Research Centre , have been studying dementia treatments for more than a decade but the breakthrough came when Arne discovered that the gene therapy was able to impact a protective enzyme in the brain with outstanding impacts on memory in advanced dementia.

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You would like volunteer and do not know your testosterone level; we would still love to hear from you. Magdalenas research primarily focuses on identifying, and testing novel treatments for neurodegenerative diseases, as well as utilizing specific models to better understand mechanisms underlying neur… View full profile. E-mail: samantha. Research output per year. After working in community … View full profile. Phase 1 clinical trial to investigate the effects of coconut oil specifically medium-chain triglycerides on ketone body production and cognitive function for the prevention of Alzheimer's disease in healthy older adults. Research output Research output per year 67 Article 12 Review article 3 Chapter 2 Editorial 1 More 1 Preprint. In vivo disease models The Dementia Research Centre is home to one of the largest colonies of genetically modified mouse models of dementia in Australia. The current discovery research program of the Dementia Research Centre strives to identify novel disease mechanisms and reveal new avenues to treat these devastating conditions. E-mail: emily. To overcome these limitations, the Dementia Research Centre has brought together experts in cellular neurobiology and peptide hydrogel chemistry and developed new 3D neuronal culture systems, based on our proprietary matrix technology. Ittner, L. Projects Projects per year 1 Not started 4 Active 23 Finished.

Our vision is a world without MND. Our mission is to provide world-class care for people living with MND and to develop new effective treatments for this devastating disease.

E-mail: kanishkapushpitha. A competitive advantage of the Dementia Research Centre is the direct access to new disease models through its direct operation of the Genome Editing Macquarie service. Would you like to volunteer for a clinical trial? Director and group leader. Daryl Ariawan daryl. E-mail: annika. Search this site. Currently a Postdoctoral Fellow at Macquarie University in the Dementia Research Centre, focusing on the pathogenesis of Alzheimer's disease and related gene-target therapy. Research teams: Delerue group Ke group Fath group. To overcome these limitations, the Dementia Research Centre has brought together experts in cellular neurobiology and peptide hydrogel chemistry and developed new 3D neuronal culture systems, based on our proprietary matrix technology. Ittner, L. E-mail: miheer. After completing her undergraduate Honours year under the supervision of Prof Thomas Fath in the Neurodegeneration and Repair Unit, Holly began working as a Research Assistant within the… View full profile.