Fernanda cisneros

Handling Editor: David Glover. Nuno M. Earnshaw; H3K9me3 maintenance on a human artificial chromosome is required for fernanda cisneros but not centromere epigenetic memory.

Background: In cancer cells, transcriptional gene silencing has been associated with genetic and epigenetic defects. The disruption of DNA methylation patterns and covalent histone marks has been associated with cancer development. In particular, miRb1 has been suggested to be an miRNA with tumor suppressor activity, and it has been shown to be deregulated in various human cancers. In the present study, we evaluated the DNA methylation at the CpG island proximal to the transcription start site of miRb1 in cancer cell lines as well as in normal tissues and gynecological tumor samples. In addition, we analyzed the association of CTCF and covalent histone modifications at the miRb1 locus.

Fernanda cisneros

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Sign in. Natalia Y.

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Our understanding of the structure and function of mitotic chromosomes has come a long way since these iconic objects were first recognized more than years ago, though many details remain to be elucidated. In this chapter, we start with the early history of chromosome studies and then describe the path that led to our current understanding of the formation and structure of mitotic chromosomes. We also discuss some of the remaining questions. It is now well established that each mitotic chromatid consists of a central organizing region containing a so-called "chromosome scaffold" from which loops of DNA project radially. These proteins are concentrated along the axis of the chromatid. Condensins I and II are primarily responsible for shaping the chromosome and the scaffold, and they produce the loops of DNA by an ATP-dependent process known as loop extrusion. Modelling of Hi-C data suggests that condensin II adopts a spiral staircase arrangement with an extruded loop extending out from each step in a roughly helical pattern.

Fernanda cisneros

J Cell Sci 15 July ; 14 : jcs First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Nuno conducted the research described in this article while a PhD student in William C. He is now a postdoc in the lab of Ting Wu at Harvard Medical School, Boston, USA, where his research interests lie in the structural and dynamic chromatin regulation of the more mysterious regions of the cell nucleus, such as centromeres, repetitive elements and nucleoli. Fernanda conducted the research described in this article while a postdoc in William C.

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J Cell Sci 15 July ; 14 : jcs This site uses cookies. Hiroshi Kimura. PDF Link Peer review history. CTCF repressive histone marks abundance was evaluated by chromatin immunoprecipitation assays. These effects were observed in other gynecological cancers, including ovarian and cervical tumors. Online ISSN: Background: In cancer cells, transcriptional gene silencing has been associated with genetic and epigenetic defects. Table of contents alert. Tatsuo Fukagawa Kochanova

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Table of contents alert. We observed a significant reduction on the expression of miRb1 in cancer cells in comparison with controls, suggesting that DNA methylation at the CpG island might reduce miRb1 expression. Tatsuo Fukagawa. Cite Icon Cite. H3K9me3 maintenance on a human artificial chromosome is required for segregation but not centromere epigenetic memory In collection: Exploring the Nucleus. People who know JCS well will know that we're more than just a journal and that our community — the cell biology community — really is at the heart of everything we do. Handling Editor: David Glover. Volume , Issue Previous Article Next Article. Article history Received:. Natalia Y.