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Background: Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives: To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Design: Prospective case series and database study. Setting: Twenty European centers.

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Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Patients Patients were recruited from January 1, , to December 31, Main Outcome Measures Based on diagnostic criteria published by the PNS Euronetwork consortium, clinical characteristics of classic PNS and several other less well-characterized syndromes associated with cancer were assessed. Results Data from patients were analyzed, representing the largest PNS investigation to date. The findings elucidate the clinical evolution of paraneoplastic cerebellar syndrome according to the onconeural antibodies present, the heterogeneity and prognosis of dysautonomic disorders, and the clinical variability of paraneoplastic limbic encephalitis. Conclusion The study results confirm that PNS influences oncologic patient survival. Tumors are the main cause of death, but some types of PNS such as dysautonomia have a poorer prognosis than malignant neoplasms. Paraneoplastic neurologic syndrome PNS can affect any part of the nervous system. Rarely, they are seen in the course of an oncologic disease. Survival is usually influenced by the oncologic disease, but PNS can cause severe disability and may be fatal. The lack of extensive clinical and epidemiologic studies on these rare disorders prompted establishment of the PNS Euronetwork by 20 consortium members from 11 European countries. Between January 1, , and December 31, , the partnership collected information on patients, resulting in the largest database on PNS to date.

In patients with PCD, euronetwork, the most frequent findings were subacute onset of moderate

Background and purpose: To describe the characteristics of patients presenting a paraneoplastic cerebellar degeneration without classical onconeural antibodies seronegative PCD. No significant difference between the clinical characteristics of seronegative and seropositive PCD patients was observed. Yet the frequency of associated tumors was different. Seronegative and seropositive PCD patients with similar tumors had a similar overall survival. Conclusion: The clinical characteristics of seronegative and seropositive PCD are similar but the spectrum of associated tumors is different.

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Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies.

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Paraneoplastic stiff person syndrome was characterized by rigidity of limbic muscles in 6 patients and of axial muscles in 3 patients. One hundred seventeen patients with features of an SN also had distal motor involvement. Keywords: onconeural antibodies; paraneoplastic cerebellar degeneration. Other frequent findings were joint position alterations Levine SM Cancer and myositis: new insights into an old association. Patients Patients were recruited from January 1, , to December 31, Obtained funding : Giometto, Vitaliani, and Honnorat. We use cookies to make our services work and collect analytics information. Anti-Hu—associated brainstem encephalitis. The outcome status was available in Paraproteinemic neuropathies and myasthenia with thymoma were excluded. Objectives To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. The relative distribution of disorders confirmed cerebellar degeneration and sensory neuronopathy were the most frequently appearing PNS. English EN. Clinical profile of syndromes.

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The present study confirms that PNS influences oncologic patient survival. Dysautonomia was diagnosed in 51 patients, 14 with isolated intestinal pseudoobstruction and 37 with SN, limbic, or brainstem encephalitis. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Arch Neurol. Tumour treatment was instead the most frequent option and chemotherapy was used in The clinical characteristics of the individual syndromes were recorded, permitting a descriptive analysis of clinical findings. You've rejected analytics cookies. The analysis of peripheral neuropathies demonstrated that other subtypes in addition to SN may be paraneoplastic. The onconeural antibody profile reflects previous data in the literature demonstrating that Hu and Yo are the most prevalent onconeural antibodies. Abstract Background: Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Abstract Background and purpose: To describe the characteristics of patients presenting a paraneoplastic cerebellar degeneration without classical onconeural antibodies seronegative PCD. This Issue. March