Dr raul p de guzman

Brill Nijhoff. Brill Wageningen Academic. Brill Fink.

The ultimate goal is to develop novel therapeutics strategies for patients with this rare disease. We aim to understand the role of endosomal ion transport for neuronal function, with focus on two endo-lysosomal transporters, ClC-3 and ClC-4, that regulate the pH and [Cl-] in multiple endosomal compartments. A group of neurodevelopmental disorders, in which slight changes in ClC-3 or ClC-4 transport functions cause epilepsy and intellectual disability as well as anxiety, depression, hyperactivity, and bipolar disorders, illustrate the importance of these transporters for higher brain functions. We use transgene technology genetically modified mouse models and shRNA lentiviral transduction , patch-clamp electrophysiology, membrane cell capacitance measurements, carbon fiber amperometry, photolytic uncaging of intracellular calcium, molecular biology, and confocal microscopy to understand the cellular and molecular function of ClC-3 and ClC-4 in neuronal health and disease and to identify potential strategies for the treatment of CLCN3- and CLCN4-related disorders. Comini, M. A, Franzen, A.

Dr raul p de guzman

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Slavic and Eurasian Studies. Review a Brill Book. Latest Financial Press Releases and Reports.

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Dr raul p de guzman

Zeus A. Ledivina V. Books and Monographs. Guzman, Raul P. Patterns in Decision-Making. Abueva, Jose V. Foundations and Dynamics of Filipino Government and Politics. Manila: Bookmark, Manila: College of Public Administration, U. Guzman, Raul P de and Ma.

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Modified from Comini, M. MARC Records. Review a Brill Book. Mission Statement. Specialty Products. LibLynx Access Management. Buy instant access PDF download and unlimited online access :. Fonts, Scripts and Unicode. Email Newsletter Sign-up Pages. Imprints and Trademarks.

After completing his residency in general surgery, he undertook research training in the Cardiology Branch of the National Heart, Lung and Blood Institute at the National Institutes of Health in Bethesda, MD and subsequently completed a fellowship in vascular surgery at Stanford University Hospital.

About us. Data Sharing Policy. Publishing contacts. View Full Size. Fonts, Scripts and Unicode. We aim to understand the role of endosomal ion transport for neuronal function, with focus on two endo-lysosomal transporters, ClC-3 and ClC-4, that regulate the pH and [Cl-] in multiple endosomal compartments. Add to Cart. Human Rights and Humanitarian Law. Latest Financial Press Releases and Reports. Brill Fink. Mission Statement. A Excitability properties recorded from wild-type neurons at the CA2 hippocampal region using acute hippocampal slice preparation. Modified from Comini, M. Investor Relations.