Dehp full form

Federal government websites often end in, dehp full form. The site is secure. Diethylhexyl phthalate DEHP is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. Due to the overuse of DEHP in many products, it enters and dehp full form the environment through release from industrial settings and plastic waste disposal sites.

Di 2-ethylhexyl phthalate DEHP is a man-made chemical. It is a colorless liquid with a slight odor. DEHP is found throughout the environment at low levels. It gets into the environment mostly through the disposal of plastic waste in landfills. Most DEHP in the environment is found in sediments and soil. It sticks strongly to soil and breaks down slowly when it is near the surface. Indoors, DEHP can also stick to dust particles.

Dehp full form

If you have any questions, comments, or concerns about the content of this page, please contact us. Di 2-ethylhexyl phthalate DEHP. DEHP is on the Proposition 65 list because it can cause cancer and birth defects or other reproductive harm. Exposure to DEHP may increase the risk of cancer, and may also harm the male reproductive system. Exposure to DEHP during pregnancy may affect the development of the child. Proposition 65 requires businesses to determine if they must provide a warning about exposure to listed chemicals. What is DEHP? DEHP belongs to a family of chemicals called phthalates, which are added to some plastics to make them flexible. In the past, DEHP was one of the phthalates most frequently used in plastic products, but its use has decreased in recent years for a variety of reasons. DEHP is still used in various types of plastic consumer products, including some: Shower curtains, furniture, and automobile upholstery, garden hoses, floor tiles, and coverings on wires and cables. Rainwear and shoes. Lunchboxes, binders, and backpacks. Plastic food packaging materials. Medical devices and equipment, including some types of blood and intravenous solution bags, tubing for dialysis, feeding tubes, oxygen masks, and surgical gloves.

Hansen J.

DEHP is the most common member of the class of phthalates , which are used as plasticizers. It is the diester of phthalic acid and the branched-chain 2-ethylhexanol. This colorless viscous liquid is soluble in oil, but not in water. Di 2-ethylhexyl phthalate is produced commercially by the reaction of excess 2-ethylhexanol with phthalic anhydride in the presence of an acid catalyst such as sulfuric acid or para -toluenesulfonic acid. It was first produced in commercial quantities in Japan circa and in the United States in DEHP has two stereocenters, [8] located at the carbon atoms carrying the ethyl groups.

Chemical Classification: Phthalates. Summary: Di 2-ethylhexyl phthlate DEHP is a manufactured chemical that is commonly added to plastics to make them flexible. DEHP is a colorless liquid with almost no odor. DEHP is present in plastic products such as wall coverings, tablecloths, floor tiles, furniture upholstery, shower curtains, garden hoses, swimming pool liners, rainwear, baby pants, dolls, some toys, shoes, automobile upholstery and tops, packaging film and sheets, sheathing for wire and cable, medical tubing, and blood storage bags. ToxFAQs - Fact sheet that answers the most frequently asked questions about a contaminant and its health effects. Toxicological Profile - Succinctly characterizes the toxicologic and adverse health effects information for a hazardous substance. ToxGuide pdf icon [ KB] - Quick reference guide providing information such as chemical and physical properties, sources of exposure, routes of exposure, minimal risk levels, children's health, and health effects for a substance. Priority List of Hazardous Substances - Prioritization of substances based on a combination of their frequency, toxicity, and potential for human exposure at National Priorities List NPL sites. Minimal Risk Levels MRL - The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure. The information in this MRL serves as a screening tool to help public health professionals decide where to look more closely to evaluate possible risk of adverse health effects from human exposure.

Dehp full form

The toxicity to exposure ratio for different human populations and scenarios has been used to derive the MOS. For the scenarios on production and industrial use, monitored data for inhalation exposure and modelled values for dermal exposure have been used as a realistic worst case. For the scenario industrial end-use of products containing DEHP, it is assumed that relatively high work temperatures, aerosol generation and considerable skin contact occur. There is not enough quantitative and qualitative information available on technical control measures and personal protective equipment used during production and processing to establish their effectiveness. There is concern for the testicular effects, fertility , toxicity to kidneys, on repeated exposure and developmental toxicity for workers as a consequence of inhalation and dermal exposure during production, processing and industrial end-use of preparations or materials containing DEHP. There is no concern for the acute toxicity, irritation and sensitising effects, carcinogenicity , and mutagenicity.

Taqueria adela

As most 2-ethylhexanol is produced as a racemic mixture, commercially-produced DEHP is therefore almost always racemic as well, and consists of equal amounts of all three stereoisomers. No studies have evaluated the potential for DEHP to cause cancer in humans, while exposure to high doses of DEHP for a long period of time resulted in liver cancer in rats and mice. Journal of applied toxicology. In addition to rats, the neurotoxicity of DEHP has also been observed in Caenorhabditis elegans , a nematode. Mitchell F. Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated. The ovaries are a significant primary reproductive organ that plays an important role in female gamete production and the release of sex hormones. The effects of di 2-ethyl hexyl phthalate DEHP on cellular lipid accumulation in HepG2 cells and its potential mechanisms in the molecular level. DEHP decreases the expression of steroidogenic acute regulatory protein StAR mRNA in pregnant mice, which reduces steroidogenesis catastrophically in both mice and humans. First trimester phthalate exposure and male newborn genital anomalies. Noriega N. When DEHP enters the body, it is metabolized into different metabolites. Toxicology and Applied Pharmacology. Dalgaard M. These alternative polymers are naturally flexible and thus do not require a softening agent.

DEHP is the most common member of the class of phthalates , which are used as plasticizers.

Pubertal administration of DEHP delays puberty, suppresses testosterone production, and inhibits reproductive tract development in male Sprague-Dawley and long-evans rats. Hillman et al. Abstract Diethylhexyl phthalate DEHP is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. Exposure to phthalates affects calcium handling and intercellular connectivity of human stem cell-derived cardiomyocytes. DEHP can also inhibit follicle growth via oxidative stress [ 50 ]. As a library, NLM provides access to scientific literature. Mitchell F. Do not allow babies and children to chew on plastic objects not made for that purpose. Jiaxiang Chen: nc. Possible role of phthalate in the pathogenesis of endometriosis: In vitro, animal, and human data.