Apoprotein

Apoproteins are the proteins of lipoproteins, apoprotein. Apoprotein functions of several are known to apoprotein lipolytic enzyme activities and lipoprotein uptake into cells. The effects of overweight were studied on the rates of production and removal of some of these proteins.

Apolipoproteins are proteins that bind lipids oil-soluble substances such as fats, cholesterol and fat soluble vitamins to form lipoproteins. They transport lipids in blood, cerebrospinal fluid and lymph. The lipid components of lipoproteins are insoluble in water. However, because of their detergent-like amphipathic properties, apolipoproteins and other amphipathic molecules such as phospholipids can surround the lipids, creating a lipoprotein particle that is itself water-soluble, and can thus be carried through body fluids i. In addition to stabilizing lipoprotein structure and solubilizing the lipid component, apolipoproteins interact with lipoprotein receptors and lipid transport proteins, thereby participating in lipoprotein uptake and clearance. They also serve as enzyme cofactors for specific enzymes involved in the metabolism of lipoproteins.

Apoprotein

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Clinical Chemistry and Laboratory Medicine. ApoA-IV synthesized in hypothalamus is suggested to be a satiating factor which regulate the food intake of the rodent, apoprotein. Different lipoproteins contain different classes of apolipoproteins, which influence apoprotein function.

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Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. NCBI Bookshelf. Daniella Lent-Schochet ; Ishwarlal Jialal. Lipoproteins are lipid transport molecules that transport plasma lipids. Specific lipoproteins are risk factors for cardiovascular disease and other metabolic diseases. Understanding lipoproteins and the different ways in which to manipulate their metabolism is an essential step towards preventing disease and morbidity in the general population. This review will highlight the cellular and molecular function of lipoprotein metabolism, how it is useful in diagnostic testing, its role in disease pathology, and its clinical significance.

Apoprotein

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Apolipoproteins are important structural components of plasma lipoproteins that influence vascular biology and atherosclerotic disease pathophysiology by regulating lipoprotein metabolism. Clinically important apolipoproteins related to lipid metabolism and atherogenesis include apolipoprotein B, apolipoprotein B, apolipoprotein A-I, apolipoprotein C-II, apolipoprotein C-III, apolipoprotein E and apolipoprotein a. Apolipoprotein B is a truncated isoform of apolipoprotein B that forms the backbone of chylomicrons. Apolipoprotein A-I provides the scaffolding for lipidation of HDL and has an important role in reverse cholesterol transport. Apolipoprotein a covalently binds to apolipoprotein B to form lipoprotein a.

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In lipid transport, apolipoproteins function as structural components of lipoprotein particles, ligands for cell-surface receptors and lipid transport proteins, and cofactors for enzymes e. Clinical Chemistry and Laboratory Medicine. Journal of Thrombosis and Haemostasis. Apolipoprotein e3 Apoe3. Bibcode : Sci Apolipoprotein synthesis such as ApoA4 in hypothalamus involves in the integration of signals for regulation of food intake [5] which is regulated by vagal nerve and cholecystokinin. It is thought to act primarily in reverse cholesterol transport [4] and intestinal lipid absorption via chylomicron assembly and secretion. Journal of Lipid Research. Article Talk. Proteins that bind lipids to transport them in body fluids. Publication types Research Support, Non-U.

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ApoE is the major lipoprotein in the central nervous system. High-density lipoprotein cholesterol falls in obesity; yet our studies of the metabolism of the major proteins of HDL apo-AI and apo-AII , showed that the formation of these increased with overweight. May ApoD level increases in nervous system with a large number of neurologic disorders inclusive of Alzheimer's disease, schizophrenia, and stroke. Wikimedia Commons. Apolipoprotein synthesis in the intestine is regulated principally by the fat content of the diet. PMID Abstract Apoproteins are the proteins of lipoproteins. Category : Apolipoproteins. Since a major function of apo-AI and of HDL is to transport cholesterol, the increased production of HDL particles in terms of proteins , is consistent with the increased need to transport additional cholesterol which is a feature of obesity. Toggle limited content width. The turnover of the apo-C group of apoproteins was not affected by overweight. PMC