Alpha inhibin

Federal government websites often end in. The site is secure. As a result of its expression in corresponding normal cell types, alpha inhibin, inhibin alpha INHA is used as an immunohistochemical marker for adrenocortical alpha inhibin and testicular or ovarian sex cord stromal tumors. However, other tumors can also express INHA.

Inhibin is a peptide hormone that is produced by ovarian granulosa cells which inhibits the release of Follicle-Stimulating Hormone FSH. The Inhibin alpha antibody subunit is expressed in a wide range of human tissues outside the reproductive axis such as prostate, brain, adrenal, as well as in the granulosa cells of the ovary, Sertoli cells of the testis and various cells of the fetoplacental unit. Inhibin may be used as a differential marker for adrenocortical tumors, placenta and gestational trophoblastic lesions and sex cord stromal tumors. Normal testis or normal ovary, adrenal gland. Groome, N G et al Monoclonal and polyclonal antibodies reactive with the amino terminal sequence of the alpha subunit of human 32K inhibin. Hybridoma 9 1 : 2. Groome, N G et al Preparation of monoclonal antibodies to beta A subunit of ovarian inhibin using a synthetic peptide immunogen.

Alpha inhibin

Click here to buy online! Inhibins are peptide hormones produced by the granulosa cells in female follicles and by Sertoli cells in the male seminiferous tubules. They are selectively expressed by cells of sex-cord stromal derivation, and inhibit the secretion of follitropin by the pituitary gland. Inhibin contains an alpha and beta subunit linked by disulfide bonds. Two forms of inhibin differ in their beta subunits A or B , while their alpha subunits are identical. Inhibin belongs to the transforming growth factor-beta TGF-beta family. Sex-Cord Stromal Tumors of the Ovary as well as Trophoblastic Tumors also demonstrate cytoplasmic positivity with this antibody. Availability Catalog No. Skip to content. Facebook page opens in new window Twitter page opens in new window Instagram page opens in new window. Inhibin Alpha R1 , MMab. United States.

Breast Calponin.

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It appears that your browser has cookies disabled. The website requires your browser to enable cookies in order to login. Don't have a login? Register today to view list prices and apply for an account to purchase online! Inhibins and activins play a role in the regulation of pituitary follicle stimulating hormone FSH secretion. The actions of inhibins and activins are thought to oppose one another, with inhibins suppressing FSH secretion and activins stimulating FSH secretion. Inhibins are secreted by granulosa cells in female follicles and Sertoli cells of the testis in the male.

Alpha inhibin

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

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Tissue Microarrays; pp. Breast Calponin. These tumors were distributed across 48 TMA blocks containing between 80 and tissue spots with a diameter of 0. Inhibins are peptide hormones produced by the granulosa cells in female follicles and by Sertoli cells in the male seminiferous tubules. Jorda M. Due to the rareness of immunohistochemically detectable INHA expression in most cancer types, we were only able to compare INHA immunostaining data with available clinical data in neuroendocrine tumors, clear cell renal cell carcinoma, and colorectal adenocarcinoma. This approach has been suggested by the international working group for antibody validation IWGAV for the validation of IHC assays designed for formalin-fixed tissues [ 33 ]. Email Cart. Download Data Sheet. Clear cell tubulo papillary renal cell carcinoma. Small cell neuroendocrine carcinoma of the bladder. Received Sep 22; Accepted Oct 3. The fact that the vast majority of these tumors showed a strong INHA expression in our study is thus consistent with the literature and confirms the utility of INHA immunostaining for supporting these diagnoses [ 40 ]. Inhibin is a peptide hormone that is produced by ovarian granulosa cells which inhibits the release of Follicle-Stimulating Hormone FSH.

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Flemming P. This was independent of the tumor type. Non-invasive papillary urothelial carcinoma, pTa G3. Weissferdt A. United States. We welcome suggestions or questions about using the website. Davis A. Answer C is incorrect as granulosa cell tumors will stain strongly for inhibin; however, they typically show minimal staining for reticulin. Board review style answer 1. We therefore analyzed INHA expression in more than 15, tumor tissue samples from different tumor types and subtypes, as well as 76 non-neoplastic tissue categories by immunohistochemistry IHC in a tissue microarray TMA format in this study. Khalil Helou, Academic Editor. Inhibin A-subunit cDNAs from porcine ovary and human placenta. The biological role of focal low-level or even diffuse high-level INHA expression in cancers derived from cells that normally do not express INHA is unknown. Center for Disease Control Manual. An experienced pathologist performed manual analysis of the stained TMA slides.